IVF is termed to have failed repeatedly when there is failure to achieve clinical pregnancy even after transfer of at least four good quality embryos in a minimum of three fresh or frozen cycles in women under 40 years of age. While most of the ART (Assisted Reproductive Technology) clinics report an implantation rate of 40-60%, the exact incidence in lacking due to the difference in. definition of implantation.
Repeated IVF failure can be attributed to quite a few reasons. These can be embryo related, parental chromosomal abnormalities which leads to abnormal embryo formation or oocyte aneuploidies dur to advanced maternal age.
A few other causes listed are:
High sperm DFI (DNA Fragmentation Index)
Intra-Uterine adhesions (scar tissue)
Congenital abnormalities in uterus
Presence of Hydrosalpinx
Defective endometrial receptivity
It is imperative to determine the reason behind the repeated failure of IVF before taking a look at the treatment options. For diagnosing the cause of repeated IVF failure uterine evaluation through Hysteroscopy comes handy.
Endometrial Receptive Array (ERA) is used to evaluate the receptivity of the uterus. This helps in determining the time when the uterus is completely ready to receive the embryo and the procedure can be scheduled accordingly. When high sperm DFI causes repeated IVF failure, advanced technology like MACS during ICSI can be chosen for selection of sperm with low DFI.
The couple must maintain a healthy lifestyle along with proper diet, regular meditation, yoga, exercise and refrain from smoking, alcohol and habit-forming drugs during the course of treatment. Patients must also be mindful of approaching a proper IVF consultant and IVF center to avoid the stress of failure. Better results can be achieved by following the proper guidelines and instructions by the consultant.
Recommended Procedures after Repeated IVF Failures can be -
Scheduling a consultation with a fertility counsellor
PGS to check the embryos in your next IVF before implantation
Becoming a mother is the greatest gift a woman can have. Are you planning to undergo IVF treatment but are a little worried because of the current COVID-19 situation? It’s quite natural if you are getting such feelings.