A miscarriage after an IVF process could be extremely disheartening for both the couple and the IVF expert. In recent years, an extra activity of immune cells or natural killer cells has emerged as the biggest reason behind these failed IVF pregnancies or miscarriages. On an average, when a woman, under the age group of 35, faces the pain of multiple miscarriages, then mostly, experts prefer to go for a test where they can study the function of the natural killer cells.
Natural killer cells are the cells that make a natural occurrence in the blood cells in the form of lymphocytes or white blood cells. Certain parts of the body like Spleen, Bone marrow produces these cells, and from there, these cells circulate in the blood to take care of various attacks of infections, tumors, viruses etc. These Natural killer cells help the body in adapting an immune response for the body.
Just like many other parts of the body, Natural killer cells appear on the uterus as well. Now, with the advancement in the studies, experts are studying their appearance in this region separately. They are trying to deduct their exact role to develop a natural killer cell treatment for an embryo. Based on the current findings, we can say that Natural killer cells affect the maternal-fetal interface of the placenta. If we go by a decade-by-decade breakdown of Natural killer cells, then we will find that, in the decade of the 50’s, the natural killer cells treatment was a forthcoming possibility in the future, because NK cells may play a part in the pregnancy. During the 60’s, this concept of foreign body attack came into existence. During this period, a theory was proposed, which suggested that, natural killer cells may recognize the embryo as a foreign body and attack it, and this attack can further increase the risk of miscarriage.
Immunological fertility is a term derived in common parlance, under which, people discuss the Natural killer cells’ functions and their impact over the embryo inside the body of women. Ideally, when an IVF expert suggests any NK cells test, then actually he or she is trying to judge the exact activity level of the immune NK cells through IVF in the body of women. Primarily, the function of immune cells or natural killer cells is the early detection and elimination of foreign cells that can cause tumors or other cancerous growths in the body. Natural killer cells prevent these harmful growths. Many experts, across the world, are of the belief that the mechanism of Natural killer cells treats the embryo as a bunch of foreign cells and starts attacking it. This theory of “natural killer cells” attacking an embryo is under the scanner of experts in many aspects.
Natural Killer Cell Activity and their impact on the pregnancy and miscarriage are still unproven in many ways. Most experts suggest NK activity tests under two conditions