1. Advanced Mateal Age and Egg Quality
It is widely known that as women age, their odds of becoming pregnant decrease. The quality and number of women's eggs reduce as they age. A drop in egg number and, notably, quality reduces the likelihood of a clinical pregnancy or live birth with IVF treatment. The best age to undergo the treatment is by 35.
2. Poor Embryo or Sperm Health
Sometimes an egg will fertilise but produce a poor quality embryo. This could be related to egg or sperm quality issues, as well as random chromosomal abnormalities. When an embryo is not healthy, it may not implant or grow properly in the womb, which can result in miscarriage. Preimplantation genetic testing is available in some clinics like Progenesis Fertility Center to assess an embryo's health before transferring it to the womb to reduce the risk of pregnancy loss, but it does not guarantee that a baby will be born free of genetic defects.
Also Check: How soon after a failed IVF can i try again?
3. Uterine and Endometrial Receptivity Issues
Embryos sometimes fail to implant in the uterus. This could be due to the existence of uterine polyps, an early spike in progesterone levels, an abnormally thin endometrial lining, or a uterine infection. It is crucial to understand that it is not your fault if an embryo fails to implant because implantation complications are usually beyond anyone's control.
4. Hormonal Imbalances and Underlying Medical Conditions
Progesterone and estrogen are two essential components for pregnancy. When present in sufficient quantities, they thicken the uterine lining, preparing the womb for implantation. If your estrogen or progesterone levels are too low or too high, your doctor may suggest freezing the eggs/embryos until your hormones are in a state of balance.
Medical conditions like the following can also be a cause for IVF failure:
Endometriosis can cause IVF failure by lowering egg reserve and embryo quality while also making the uterine lining less susceptible to implantation.
PCOS causes hormonal imbalances and can interfere with IVF success. Fortunately, IVF success rates for women with PCOS remain high and many women whose IVF fails due to this condition are eventually able to conceive successfully with another cycle.
Autoimmune disorders
Autoimmune disorders can cause IVF to fail because the body misidentifies the embryo as a threat and attacks it. Medication can help lower immune system overactivity, hence improving fertility.
Also Read: Can I get pregnant after a failed IVF?
5. Lifestyle Factors and Environmental Influences
Your BMI, diet, and smoking habits can all have an impact on whether or not your IVF cycle will be successful. Several scientific studies have shown that women who are overweight or obese have less successful results in assisted reproduction treatments as the ovaries do not respond as well to hormones, and the chances of a live birth decrease while the risks of miscarriage increase. Getting to a healthy weight with a pro-fertility diet along with plenty of exercise, as well as quitting smoking if you smoke, are excellent ways to naturally increase your fertility.
Your environment also plays an important role in your fertility. Hot working environments can reduce sperm quality in men. Discuss viable solutions with your doctor to avoid fertility damage in such cases and avoid taking long sauna or hot bath sessions if you are on your parenthood jouey.
6. IVF Laboratory and Procedure‑Related Quality Factors
IVF procedures can sometimes be unsuccessful when done at the wrong laboratory setting or under the expertise of an inexperienced embryologist. The air quality, equipment functioning, light sensitivity and presence of bacteria in the lab all play an important role in your IVF success. Your embryologist’s skills in creating the embryo by fertilising the sperm and eggs also determine the quality and receptivity of the embryos. Which is why it is necessary to get your treatment done from a reputed fertility clinic like Progenesis Fertility Center where the doctors involved have years of experience in the field and know how to successfully conduct the treatment without any errors.
7. Emotional & Psychological Stress and Unrealistic Expectations
Individuals undergoing IVF frequently encounter a rollercoaster of emotions. Anger is a normal emotion throughout this period, as people may be upset with their own bodies. Persistent disappointment can also lead to feelings of hopelessness and anxiety. It is important to have realistic expectations from your treatment and not give up hope after your first one or two cycles fail. In the meantime, developing coping mechanisms is critical for mental health in this jouey. Joualing can help people process their emotions. Establishing a support network is also critical. Mindfulness techniques can also help reduce anxiety levels.
Also Read: Tips to Cope with Failure of First IVF Cycle Attempt
